Work

The Role of Mechanical Loading in Tendon Development, Maintenance, Injury, and Repair

Year: 2013

Type: review

Abstract: Tendon injuries often result from excessive or insufficient mechanical loading, impairing the ability of the local tendon cell population to maintain normal tendon function. The resident cell population composing tendon tissue is mechanosensitive, given that the cells are able to alter the extracellular matrix in response to modifications of the local loading environment. Natural tendon healing is insufficient, characterized by improper collagen fibril diameter formation, collagen fibril distribution, and overall fibril misalignment. Current tendon repair rehabilitation protocols focus on implementing early, well-controlled eccentric loading exercises to improve repair outcome. Tissue engineers look toward incorporating mechanical loading regimens to precondition cell populations for the creation of improved biological augmentations for tendon repair.

Source: Journal of Bone and Joint Surgery

DOI: 10.2106/jbjs.l.01004

Authors: Marc T. Galloway, Andrea L. Lalley, Jason T. Shearn

Institutions: Cincinnati Sportsmedicine and Orthopaedic Center, University of Cincinnati

Language: English

Topic: Tendon Structure and Treatment

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1992702004

FWCI: 1.798

Cites: 146

Cited by: 283

Related to: 10