Work

Highly Efficient “Grafting onto” a Polypeptide Backbone Using Click Chemistry

Year: 2009

Type: article

Abstract: “Clicked” into place: Densely grafted poly(γ-propargyl-L-glutamate)-g-poly(ethylene glycol) polypeptides have been synthesized by combining ring-opening polymerization of N-carboxyanhydrides with click chemistry. Various lengths of poly(ethylene glycol) (PEG) side chains (750 g mol−1 to 5000 g mol−1) were attached to a rigid α-helical poly(γ-propargyl-L-glutamate); extremely high grafting efficiencies of over 96 % were achieved.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200904070

Authors: Amanda C. Engler, Hyung‐il Lee, Paula T. Hammond

Institutions: Massachusetts Institute of Technology, University of Ulsan

Language: English

Topic: Advanced Polymer Synthesis and Characterization

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of Biomedical Imaging and Bioengineering

Award: Dendritic Block Copolymer Micelles as New Targeted Drug Delivery Systems