Work

Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand

Year: 2010

Type: article

Abstract: (S)-N-methylpyrrolidine-2-carboxylate, a derivative of natural L-proline, was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides with aryl halides under mild conditions. A variety of N-arylamides were synthesized in good to high yields.

Source: Molecules

DOI: 10.3390/molecules15031154

Authors: Chaoyu Wang, Lijuan Liu, Wei Wang, Dong-Sheng Ma, Hua Zhang

Institutions: Mudanjiang Normal University, Heilongjiang University

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,258

Funders: Department of Education, Heilongjiang Province, Heilongjiang Provincial Science and Technology Department