Work

Pigmentation in vitamin B12 deficiency masquerading Addison′s pigmentation: A rare presentation

Year: 2013

Type: article

Abstract: A 35-year-female presented with generalized weakness, weight loss, and progressive pigmentation was worked up for suspicion of Addisons disease. On examination hyper pigmentation was noted on both palmar and dorsal aspect of hands involving knuckles, creases, feet, tongue, oral mucosa and gluteal region. There was no evidence of hypocortisolemia as initially suspected, and literature search revealed a possibility of vitamin B12 deficiency. She had megaloblastic anemia with a low serum vitamin B12, mostly due to poor dietary intake. Her hyper pigmentation resolved with vitamin B12 supplementation. Skin biopsy showed increased pigmentation at stratum spinosum and basal-layer. The mechanism of hyper pigmentation in vitamin B12 deficiency was due to an increase in melanin synthesis.

Source: Indian Journal of Endocrinology and Metabolism

DOI: 10.4103/2230-8210.119591

Authors: RiteshKumar Agrawala, SrikantaKumar Sahoo, ArunKumar Choudhury, BinoyKumar Mohanty, AnojKumar Baliarsinha

Institution: Sriram Chandra Bhanja Medical College Hospital

Language: English

Topic: Folate and B Vitamins Research

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W1993215136

FWCI: 1.944

Cites: 3

Cited by: 42

Related to: 10