Work

GST polymorphism and cytogenetic changes in lung tissues of lung cancer patients

Year: 2009

Type: article

Abstract: Carriers of GSTTI gene deletion were found to be more subjected to a risk of emerging non-small-cell lung cancer (NSLC) than those of normal GSTT1(+) genotype. Study on the relation between GST gene polymorphism and cytogenetic indices in lung cancer patients has shown a significant excess of the group average level in cells with micronuclei in NSLC patients with GSTTI(-). The frequency of cells with micronuclei was higher in smoking patients with a mutant genotype than in smoking carriers of the GSTT1(+) genotype.

Source: Cytology and Genetics

DOI: 10.3103/s0095452709010071

Authors: N. N. Chakova, E. P. Mikhalenko, S. N. Polonetskaya, N. V. Chebotareva, Y. E. Demidchik, A. A. Zhilko, O. V. Kvitko, E. V. Krupnova

Institutions: National Academy of Sciences of Belarus, Institute of Genetics and Cytology of the National Academy of Sciences of Belarus

Language: Russian

Topic: Glutathione Transferases and Polymorphisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1993787556

FWCI: 0.33

Cites: 12

Cited by: 9

Related to: 10