Work

Obesity: Increasing Awareness of Novel Environmental Factors

Year: 2008

Type: article

Abstract: Over the past 20 years, the molecular underpinnings of energy homeostasis have come to light (1–4) at a rate strikingly similar to that of the rising prevalence of obesity (5, 6). The fact that one is statistically more likely to be overweight or obese in the U.S. today has profound ramifications for basic scientific research, translational research, public policy, and our health care economy. Homeostatic regulation of feeding. Current obesity statistics generate a striking contrast to abundant experimental evidence indicating that body adiposity is (or can be) a remarkably tightly regulated physiological variable (7–9), much like blood glucose concentration. Studies in rodent models, many of which have been confirmed in humans, have identified a plethora of humoral signals,

Source: Diabetes

DOI: 10.2337/db08-0527

Authors: Kevin D. Niswender, Bettina M. Beech

Institutions: Vanderbilt University, VA Tennessee Valley Healthcare System, Vanderbilt University Medical Center

Language: English

Topic: Regulation of Appetite and Obesity

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institute of Diabetes and Digestive and Kidney Diseases