Discovery of a novel enzymatic cleavage site for botulinum neurotoxin F5
Year: 2011
Type: article
Abstract: Botulinum neurotoxins (BoNTs) cause botulism by cleaving proteins necessary for nerve transmission. There are seven serotypes of BoNT, A-G, characterized by their response to antisera. Many serotypes are further distinguished into differing subtypes based on amino acid sequence, some of which result in functional differences. Our laboratory previously reported that all tested subtypes within each serotype have the same site of enzymatic activity. Recently, three new subtypes of BoNT/F; /F3, /F4, and /F5, were reported. Here, we report that BoNT/F5 cleaves substrate synaptobrevin-2 in a different location than the other BoNT/F subtypes, between (54)L and (55)E. This is the first report of cleavage of synaptobrevin-2 in this location.
Source: FEBS Letters
Institutions: Centers for Disease Control and Prevention, National Center for Environmental Health, United States Army Medical Research Institute of Infectious Diseases, United States Army Medical Research and Development Command, Universidad Nacional de Cuyo, National Center for Emerging and Zoonotic Infectious Diseases
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,980
OpenAlex ID: W1995303174