Year: 2013
Type: article
Abstract: Cancer stem cells contribute to the malignant phenotypes of a variety of cancers, but markers to identify human hypopharyngeal cancer (HPC) stem cells remain poorly understood. Here, we report that the CD271(+) population sorted from xenotransplanted HPCs possesses an enhanced tumor-initiating capability in immunodeficient mice. Tumors generated from the CD271(+) cells contained both CD271(+) and CD271(-) cells, indicating that the population could undergo differentiation. Immunohistological analyses of the tumors revealed that the CD271(+) cells localized to a perivascular niche near CD34(+) vasculature, to invasive fronts, and to the basal layer. In accordance with these characteristics, a stemness marker, Nanog, and matrix metalloproteinases (MMPs), which are implicated in cancer invasion, were significantly up-regulated in the CD271(+) compared to the CD271 (-) cell population. Furthermore, using primary HPC specimens, we demonstrated that high CD271 expression was correlated with a poor prognosis for patients. Taken together, our findings indicate that CD271 is a novel marker for HPC stem-like cells and for HPC prognosis.
Source: PLoS ONE
Institutions: Tohoku University, Miyagi Prefectural Hospital Organization
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,382
Awards: Role of ESCRT proteins in the malignant phenotype control of Head and Neck Cancer Cells, Analysis of Head and Neck Cancer malignancy related to EMT and Cancer Stem Cells, Identification of a Cancer stem cell marker and therapeutic target by xenotlansplantation methods, Role of Hrs in life cycle of hepatitis C virus, G6718509927, Roles of ESCRT in Oncogenesis, Analysis of immunological reaction in liver using JFH-1 and establishment of novel therapy
OpenAlex ID: W1996591010