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Potential Applications of Imaging and Image-Guided Radiotherapy for Brain Metastases and Glioblastoma to Improve Patient Quality of Life

Year: 2013
Type: review
Abstract: Treatment of glioblastoma multiforme (GBM) and brain metastasis remains a challenge because of the poor survival and the potential for brain damage following radiation. Despite concurrent chemotherapy and radiation dose escalation, local recurrence remains the predominant pattern of failure in GBM most likely secondary to repopulation of cancer stem cells. Even though radiotherapy is highly effective for local control of radio-resistant tumors such as melanoma and renal cell cancer, systemic disease progression is the cause of death in most patients with brain metastasis. Preservation of quality of life (QOL) of cancer survivors is the main issue for patients with brain metastasis. Image-guided radiotherapy (IGRT) by virtue of precise radiation dose delivery may reduce treatment time of patients with GBM without excessive toxicity and potentially improve neurocognitive function with preservation of local control in patients with brain metastasis. Future prospective trials for primary brain tumors or brain metastasis should include IGRT to assess its efficacy to improve patient QOL.
DOI: 10.3389/fonc.2013.00284
Authors: Nam P. Nguyen, Mai L. Nguyen, Jacqueline Vock, Claire Lemanski, Christine Kerr, Vincent Vinh-Hung, Alexander Chi, Rihan Khan, William Woods, Gabor Altdorfer, Mark D’Andrea, Ulf Karlsson, Russ Hamilton, Fred Ampil
Institutions: University of Arizona, Stanford University, Lindenhofspital, University of Geneva, University Hospital of Geneva, West Virginia University, Marshfield Clinic, Marshfield Clinic, Marshfield Clinic, Louisiana State University, Louisiana State University in Shreveport
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W1996807015
FWCI: 0.12
Cites: 61
Cited by: 19
Related to: 10