Work

Potent Homophthalimide-Type Inhibitors of B16F10/L5 Mouse Melanoma Cell Invasion.

Year: 1999

Type: article

Abstract: Recently, we developed a series of novel and potent aminopeptidase inhibitors with a homophthalimide skeleton. Among them, N-(2,6-diethylphenyl)homophthalimide (PIQ-22) possesses a specific aminopeptidase-inhibiting activity more potent than that of bestatin or actinonin, as assayed in terms of hydrolysis of L-alanine 4-methylcoumaryl-7-amide (Ala-AMC) by human acute lymphoblastic leukemia MOLT-4 cells. We show here that PIQ-22 and its 2,6-dimethylphenyl derivative (PIQ-11) are more potent inhibitors of tumor cell invasion than bestatin and actinonin in a Matrigel assay using mouse melanoma B16F10/L5 cells.

Source: Biological and Pharmaceutical Bulletin

DOI: 10.1248/bpb.22.1010

Authors: Hiroyuki KAGECHIKA, Masato KOMODA, Yasuyuki FUJIMOTO, Yukiko KOISO, Hisae TAKAYAMA, Shizuo KADOYA, Keizo MIYATA, Fuminori KATO, Masanari KATO, Yuichi HASHIMOTO

Institution: The University of Tokyo

Language: English

Topic: Peptidase Inhibition and Analysis

Subfield: Biochemistry

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1997181876

FWCI: 0.274

Cites:

Cited by: 10

Related to: 10