Preparation and Properties of Nanocomposites Containing FGF-2, other Related Dressings and the Primary Animal Tests
Year: 2012
Type: article
Abstract: PU/ hydrogel composites or it containing fibroblast growth factor-2 (FGF-2) composites had been prepared by γ-ray radiation or room temperature(T) method in this paper. We utilized nanosized clay solution, thermosensitive N-isopropyl acrylamide (NIPAAm), Polyurethane (PU), and acrylic acid (AAc) as the starting materials to synthesize PU/hydrogel nanocomposite products. The dipping and weighing tests, Material Testing Machine (LLOYD) were employed to analyze the physical and mechanical properties differentially. In addition, the drug release and the wound closure in animal experiments were also finished by Enzyme-link immunosorbent assay( ELISA) reader and magnifier for five groups of treatment dressings. From the experimental results, we distinctly obtained that animal tests of the PU/hydrogel composite incorporating FGF-2 as a wound dressing was able to effectively interact with the wound in a suitable moist healing environment. From the results, we also gained that these composites make themselves more compatible with skin.
Source: Advanced materials research
Authors: Te Hsing Wu, Hong Ru Lin, Lie Han Shen
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W1997651908