SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample
Year: 2009
Type: article
Study design: Observational Study
Abstract: The CHRNA6 and CHRNB3 genes have been associated with nicotine dependence and early subjective response to nicotine. Here we present evidence, using a nationally representative sample of adults, that this region is also associated with alcohol behaviors. Six SNPs (single nucleotide polymorphisms) spanning the CHRNB3/A6 genes were analyzed using the statistical genetics software FBAT-PC, which allows one to examine a collection of multiple phenotypes to generate a maximally heritable composite phenotype for each SNP. The six SNPs were tested using FBAT-PC including four alcohol phenotypes: average number of drinks, blackouts, total number of DSM-IV abuse and dependence symptoms endorsed, and quit attempts. Three SNPs in CHRNA6 (rs1072003, P = 0.015; rs892413, P = 0.0033 and rs2304297, P = 0.012) and one SNP in CHRNB3 (rs13280604, P = 0.0053) were associated with a composite of the alcohol phenotypes. The association was primarily driven by the average number of drinks.
Source: Genes Brain & Behavior
Institutions: University of Colorado Boulder, University of Colorado System
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Awards: G1961596689, G3120255333, Research Training - Genetics of Substance Abuse, G4305750189, NYS FAMILY STUDY: PROBLEM ALCOHOL USE &PROBLEM BEHAVIOR, G5307852374, Molecular Genetics and Behavior: Alcohol and Tobacco Use, Social Demographic Moderation of Genome Wide Associations for Body Mass Index, Behavioral Pharmacogenetics of Drug and Alcohol Abuse
OpenAlex ID: W1998106835