Year: 1990
Type: article
Abstract: Transforming growth factor-fl (TGFP), a potent immunomodulatory cytokine found in inflammatory sites, is a product of hemopoietic cells.'TGFB has a broad spectrum of cellular targets and has multifunctional actions suggesting that it plays a pivotal role in many physiological and pathological processes?For example, in v i m , TGFP has been shown to induce human monocyte chemotaxis at femtomolar concentrations, and picomolar quantities stimulate the production of inflammatory mediators by monocytes?Identification of immunoreactive TGFP in inflamed synovium of rodents with erosive polyarthritis suggested a role for this polypeptide in inflammatory lesions.To define the potential role of TGFP in chronic inflammatory lesions such as arthritis, K F P l purified from bovine bone or recombinant human TGFPl was injected intra-articularly through the extensor surface of the talarnavicular joint of Lewis rats (Harlan Sprague Dawley, Indianapolis, IN)?Following injection of 1 pg TGFB/25 pl vehicle, marked swelling and erythema of the treated joints were apparent within 12 h, reaching a peak
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1998196464