Work

Total Synthesis of theGalbulimimaAlkaloid (−)‐GB17

Year: 2012

Type: article

Abstract: A tale of two Michaels: The first enantioselective total synthesis of (−)-GB17 is reported. Construction of this unique naphthoquinolizinone skeleton was achieved by two stereoselective intramolecular Michael additions, one under catalyst control and the other under substrate control.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201108227

Authors: Reed T. Larson, Michael D. Clift, Regan J. Thomson

Institution: Northwestern University

Language: English

Topic: Advanced Synthetic Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: New Methods for the Concise Synthesis of Bioactive Polycyclic Molecules