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Development of Label-Free Bioaffinity Sensor Using a Lumped-Constant Microwave Resonator Probe

Year: 2011

Type: article

Abstract: A novel label-free bioaffinity sensor using a lumped-constant microwave resonator was developed. A gold probe with a spherical tip immobilizing anti-chicken egg albumin antibody or anti-human albumin antibody on its surface was connected to the resonator and inserted into a flow cell to monitor the target antigen binding. The sensor showed specific sensitivity against its target antigen evidenced by the change of resonance frequency after the antigen injection. The large frequency shift observed during the injection of antigen solution was ascribed to the change of solution dielectric constant which showed a systematic increase with antigen concentration.

Source: Applied Physics Express

DOI: 10.1143/apex.4.017001

Authors: Noriaki Okazaki, Taito Nishino, Toyohiro Chikyow, Yasuo Cho

Institutions: Tohoku University, Research Institute of Electrical Communication, Tohoku University, Nissan Chemical Corporation (Japan), National Institute for Materials Science

Language: English

Topic: Microwave and Dielectric Measurement Techniques

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W1998433472

FWCI:

Cites: 22

Cited by: 1

Related to: 10