Atpenins, new antifungal antibiotics produced by Penicillium sp. Production, isolation, physico-chemical and biological properties.
Year: 1988
Type: article
Abstract: Penicillium sp.FO-125, a soil isolate, was found to produce a new antifungal antibiotic complex named atpenin.Three components A4, A5 and B were isolated from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and HPLC.The molecular formula of atpenins A4, A5 and B were determined to be C15H22NO5C1, Q5H21NO5G2 and C15H23NO5, respectively, on the basis of high resolution electron impact massspectrometry and elemental analysis.They are active against filamentous fungi, especially, Trichophyton sp.Drugs affecting lipid metabolism are expected to be useful for the control of hypercholesterolemia, obesity, diabetes and so on.During the course of our screening for new compounds affecting lipid metabolisms from microorganisms, triacsins A, B, C and D were isolated from the cultured broth of Streptomyces sp.SK-1894, a soil isolate.Wealso reported that triacsins are new inhibitors of acyl-CoAsynthetase and have a iV-hydroxytriazene moiety in their structure, and iV-hydroxytriazene is essential for the activity.1 »2)
Source: The Journal of Antibiotics
Institution: Kitasato University
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W1998540951