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Tolerance checkpoints in B‐cell development: Johnny B good

Year: 2009

Type: article

Abstract: B-cell development up to the immature B-cell stage takes place in the bone marrow, while final maturation into mature B cells occurs in the spleen. During differentiation, the precursor and immature B cells have to pass several checkpoints, including those in which they are censored for being auto-reactive, and therefore being potentially dangerous. Numerous studies have shown that the immature B-cell stage in the bone marrow and the transitional B-cell stages in the spleen comprise distinct checkpoints at which auto-reactivity is censored. Recently, evidence has been provided that the large pre-BII stage in the bone marrow, at which the pre-BCR is expressed, is yet another B-cell tolerance checkpoint. Here, we review these findings and speculate on directions for possible further experimentation.

Source: European Journal of Immunology

DOI: 10.1002/eji.200939633

Authors: Roxane Tussiwand, Nabil Bosco, Rhodri Ceredig, Antonius G. Rolink

Institutions: University of Basel, Nestlé (Switzerland), Ollscoil na Gaillimhe – University of Galway

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1998650076

FWCI: 2.067

Cites: 83

Cited by: 54

Related to: 10