Work

Synthesis and Anti-tubulin Activity of Ustiloxin D Derivatives.

Year: 1998

Type: article

Abstract: Ustiloxin D, produced by the rice plant pathogen Ustilaginoidea virens, exhibits potent anti-tubulin activity. In order to elucidate the effects of functional groups in ustiloxin D on its activity, several derivatives were synthesized and their anti-tubulin activities were estimated. The N,N-dimethylamino derivative and the 14-O-methyl derivative were inactive (IC50 > 50 microM). 20-Hydroxymethylated ustiloxin D showed decreased inhibitory activity compared with ustiloxin D.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.51.423

Authors: NAOKO MORISAKI, YUKIKO MITSUI, YUKIKO YAMASHITA, YUKIKO KOISO, RYUICHI SHIRAI, YUICHI HASHIMOTO, SHIGEO IWASAKI

Institutions: Institute for Quantitative Biosciences, The University of Tokyo, The University of Tokyo

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2000206119

FWCI: 0.307

Cites: 12

Cited by: 27

Related to: 10