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Antioxidative and Antigenotoxic Effects of Japanese Horse Chestnut (Aesculus turbinata) Seeds

Year: 2005

Type: article

Abstract: Japanese horse chestnut seed extract (HCSE) dose-dependently inhibited the autooxidation of linoleic acid (IC(50): 0.2 mg/ml), and the inhibition was almost complete at a concentration of 1 mg/ml. The HCSE scavenged DPPH (1,1-diphenyl-2-picrylhydrazyl) radicals and superoxide anions with EC(50)s of 0.65 and 0.21 mg/ml, respectively. However, it had no effect on hydrogen peroxide. The HCSE inhibited the genotoxicities of furylfuramide, N-methyl-N-nitrosourea, methyl methanesulfonate, mitomycin C, 2-aminoanthracene and aflatoxin B1 at a concentration of 1 mg/ml or more. Total polyphenol content of the HCSE was 21 mg/g (13 mg/g-seeds). These results indicate that the Japanese horse chestnut seed is an antioxidative and antimutagenic botanical resource.

Source: Journal of Veterinary Medical Science

DOI: 10.1292/jvms.67.731

Authors: Itaru SATO, Tadahiko SUZUKI, Haruo KOBAYASHI, Shuji TSUDA

Institution: Iwate University

Language: English

Topic: Phytochemicals and Antioxidant Activities

Subfield: Biochemistry (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2000336690

FWCI: 1.022

Cites: 27

Cited by: 24

Related to: 10