Work

A Canine Peripheral Nerve Sheath Tumor Including Peripheral Nerve Fibers.

Year: 1999

Type: article

Abstract: Peripheral nerve sheath tumor was found in a 7-year-old male mongrel dog. The tumors were located in the right cheek subcutis and oral submucosa. Histologically, neoplastic cells were arranged in streaming bundles, occasionally interlacing bundles or whorls of elongated and spindle cells. Cellular atypia was poor and mitotic figures were rarely observed. Ultrastructurally, neoplastic cells had basement membrane, typical of Schwann cells. One bundle of normal peripheral nerve fibers and some myelinated axons were seen within the tumor tissues. Immunohistochemically, neoplastic cells reacted to vimentin, glial fibrillary acidic protein, S-100 protein and neuron specific enolase. In addition to the above immunoreactions, the included nerve fibers were positive for myelin basic protein and neurofilament protein. This paper also discusses immunohistochemical findings on differential diagnosis in comparison with those of canine hemangiopericytomas reported hitherto.

Source: Journal of Veterinary Medical Science

DOI: 10.1292/jvms.61.1335

Authors: Osamu SAWAMOTO, Jyoji YAMATE, Mitsuru KUWAMURA, Rika HAGIWARA, Kazunobu KURISU

Institutions: Otsuka (Japan), Osaka Prefecture University, Otsuka Pharmaceutical Factory (Japan)

Language: English

Topic: Veterinary Oncology Research

Subfield: Small Animals

Field: Veterinary

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Otsuka Pharmaceutical