Immunosuppressive activity of 15-deoxyspergualin and its effect on skin allografts in rats.
Year: 1987
Type: article
Abstract: The immunosuppressive activity of spergualin analogues, 15-deoxyspergualin and N-30, is presented.These compounds suppressed antibody formation and establishment of delayedtype hypersensitivity to sheep red blood cells (SRBC) in mice.Amongspergualin, 15-deoxyspergualin, and N-30, 1 5-deoxyspergualin was most effective in suppressing immuneresponses.It suppressed antibody formation against SRBCby spleen cell cultures in a dose-dependent fashion without reducing cell viability.The spergualins also suppressed the mixedlymphocyte culture reaction.Peritoneal exudate cells taken from mice given immunosuppressive doses of 15-deoxyspergualin were not reduced in their functions measured: Release of lysosomal enzymes and production of superoxide anions.15-Deoxyspergualin and N-30 were markedly effective in prolonging skin graft in rats.In a previous paper, we reported that spergualin, an antitumor antibiotic, had immunosuppressive activity and was effective in prolonging skin grafts in rats0.From a study on spergualin analogues, 15-deoxyspergualin and N-30 were found to have stronger antitumor activity than spergualin itself2' 3).Wereport in this paper the immunosuppressive effects of 15-deoxyspergualin and N-30 in mice and their effect on skin allografts in rats.
Source: The Journal of Antibiotics
Institution: Microbial Chemistry Research Foundation
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2000466028