Work

Molecular pathology of prostate cancer revealed by next-generation sequencing

Year: 2013

Type: review

Abstract: PURPOSE OF REVIEW: This article reviews recently identified genomic mutations in prostate cancer. RECENT FINDINGS: Advanced sequencing technologies have made it possible to obtain large amounts of data on genomes and transcriptomes of cancers. Such technologies have been used to sequence prostate cancer of different stages, from treatment-naive cancers, to advanced, castration-resistant cancers to the aggressive small cell neuroendocrine carcinomas. For each category of prostate cancer, distinct and overlapping DNA sequence alterations were discovered, including point mutations, small insertions or deletions, copy number changes and chromosomal rearrangements. There appears to be a stepwise increase in genomic alterations from low risk to high risk to advanced cancers. SUMMARY: These novel findings have significantly increased our knowledge of the genetic basis of human prostate cancer and the molecular mechanisms responsible for disease progression and treatment resistance. Some of the lesions are potential therapeutic targets. Studies along this direction will eventually make it possible to design personalized management plans for individual patients.

Source: Current Opinion in Urology

DOI: 10.1097/mou.0b013e32835e9ef4

Authors: Jiaoti Huang, Jason K. Wang, Yin Sun

Institutions: University of California, Los Angeles, Broad Center, UCLA Jonsson Comprehensive Cancer Center

Language: English

Topic: Prostate Cancer Treatment and Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute