Synthesis, spectral linearity, antimicrobial, antioxidant and insect antifeedant activities of some 2,5-dimethyl-3-thienyl chalcones
Year: 2013
Type: article
Abstract: Twelve 2,5-dimethyl-3-thienyl chalcones [E-1-(2,5-dimethyl-3-thienyl)-3-(substituted phenyl)-2-propen-1-ones] have been synthesized by Claisen–Schmidt condensation of 3-acetyl-2,5-dimethyl furon and substituted benzaldehydes. Yields of the chalcones are more than 80%. These chalcones were characterized by their physical constants and spectral data. The group frequencies of infrared ν(cm−1) of CO s-cis and s-trans, CH in-plane and out of plane, CHCH out of plane, >CC< out of plane modes, NMR chemical shifts δ(ppm) of Hα, Hβ, CO, Cα and Cβ of these chalcones were correlated with Hammett substituent constants, F and R parameters using single and multi-regression analyses. From the results of statistical analyses, the effects of substituents on the group frequencies are explained. Antibacterial, antifungal, antioxidant and insect antifeedant activities of these chalcones have been studied.
Source: Arabian Journal of Chemistry
Institution: Annamalai University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $1,490
OpenAlex ID: W2000568997