Year: 1976
Type: article
Abstract: In the rabbit there is evidence that oestrogen, derived from the ovarian follicles, forms part of the luteotrophic complex responsible for maintenance of the corpora lutea (CL) of pregnancy and pseudopregnancy (Hilliard, 1973). Labhsetwar (1971) showed that administration of the antioestrogen, Nolvadex, to rabbits either early in pregnancy or between Days 10 and 20 of pseudopregnancy results in a reduction in the size and number of CL and concluded that the drug directly counters the luteotrophic action of oestradiol. However, there is no supporting information available on the hormonal changes following treatment with Nolvadex. We therefore treated rabbits with Nolvadex and measured plasma progesterone and oestradiol concentrations.
Source: Reproduction
Authors: B. J. A. Furr, B. Valcaccia, J. R. G. Challis
Institution: University of Oxford
Language: English
Subfield: Endocrinology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2000606729