Work

SUPEROXIDE DISMUTASE (SOD) LEVELS IN RAT BRAIN AFTER HeNe LASER IRRADIATION COMPARED TO INTRAVENOUS ADMINISTRATION OF SOD SOLUTION: AN EXPERIMENTAL MODEL FOR THE PREVENTION OF CEREBRAL VASOSPASM AFTER SUBARACHNOID HAEMORRHAGE

Year: 1991

Type: article

Abstract: Cerebral vasospasm (VS) is a major complication following a subarachnoid haemorrhage (SAH) after the rupture of a cerebral aneurysm. Many factors are involved, but many authors are now focusing on an imbalance between vasodilator and vasoconstrictor metabolites originating from the haemolysis of the subarachnoid clot. In the reported study. as a step towards establishing a multifactorial SAH therapy, we tried in a controlled experiment to enhance rat brain superoxide dismutase (SOD), EC 1.15.1.1., the natural scavenger of superoxide radicals, either by helium neon (HeNe) laser irradiation on the sinciput of rats, or by direct intravenous administration of SOD solution. In both cases we obtained a marked increase of brain total SOD, compared with the control animals and those who had simulated (sham) treatment.

Source: LASER THERAPY

DOI: 10.5978/islsm.91-or-25

Authors: Rosa Urciuoli, Paola M. Rolfo, Valeria Rossetti

Institution: University of Turin

Language: English

Topic: Laser Applications in Dentistry and Medicine

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2000665378

FWCI:

Cites: 23

Cited by: 3

Related to: 10