Clinical research on recombinant human Ad-p53 injection combined with cisplatin in treatment of malignant pleural effusion induced by lung cancer
Year: 2009
Type: article
Study design: Clinical Trial
Abstract: Chinese Journal of CancerMalignant pleural effusion is one of the common complications of advanced malignant tumors.It is usually accompanied with symptoms of chest distress, dyspnea, racing heart, and chest pain, severely influences the life quality of patients.Therefore, effective control of pleural effusion during the treatment for advanced tumors can improve life quality and prolong survival time.In this study, we used recombinant human Adp53 injection (Gendicine, rAdp53) via central venous catheterization with closed drainage, in combination with cisplatin (DDP) to treat 35 cases of pleural effusion due to lung cancer, and analyzed the treatment efficacy and adverse events.Thirtyfive lung cancer patients with malignant pleural effusion were treated in the Oncology Department of the First Affiliated Hospital of Liaoning Medical College between July 2005 and December 2008.These patients were divided randomly into the combination group and the singleagent group.Of the 17 patients in the combination group, 9 were men and 8 were women, aged 4071 years with a median of 55; 6 had squamous cell carcinoma, 9 had adenocarcinoma, and 2 had large cell carcinoma.Of the 18 patients in the singleagent group, 10 were men and 8 were women, aged 3775 years with a median of 55; 8 had squamous cell carcinoma and 10 had adenocarcinoma.The diagnoses of malignant pleural effusion were confirmed by thoracic CT examination, color thoracic ultrasound, and cytohistological examination.All patients had a KPS of 60 points for general status, with expected survival of more than 3 months.The results of electrocardiogram (ECG), liver function Clinical research on recombinant human Adp53 injection combined with cisplatin in treatment of malignant pleural effusion induced by lung cancer
Source: 癌症：英文版
Authors: Wei-Zhu Zhao, Ji-Kun Wang, Wei Li, Xiu-Li Zhang
Language: Chinese
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2000694905