Work

Reevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicism

Year: 2012

Type: article

Abstract: Recent studies have been raising doubts on the safety of induced pluripotent stem cells (iPSCs) and proposing that the process of reprogramming brought about copy number variations (CNVs) in iPSCs. However, a recent paper published in Nature provided evidence showing that most CNVs were pre-existed as somatic mosaicism but not resulted from the reprogramming. This new finding would profoundly reshape some previous thoughts and endorse the confidence of iPSCs in both research and therapy.

Source: Protein & Cell

DOI: 10.1007/s13238-012-2940-6

Authors: Wensu Liu, Ming Li, Jing Qu, Fei Yi, Guang-Hui Liu

Institutions: Chinese Academy of Sciences, Institute of Biophysics, Stanford Medicine, Stanford University

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Natural Science Foundation of China, Chinese Academy of Sciences, Thousand Young Talents Program of China, National Laboratory of Biomacromolecules