Clinical Characteristics of Patients who Developed Hepatocellular Carcinoma after Hepatitis C Virus Eradication with Interferon Therapy: Current Status in Japan
Year: 2013
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: We attempted to elucidate the clinical features of chronic hepatitis C patients who develop hepatocellular carcinoma (HCC) after achieving a sustained viral response (SVR) to interferon (IFN) therapy. METHODS: The clinical features of 130 patients at 19 hospitals who developed HCC after obtaining an SVR were retrospectively reviewed. RESULTS: Overall, 107 (82%) of the 130 patients were men, with 92 (71%) being ≥60 years of age and 76, 38 and 16 developing HCC within 5, 5-10 and 10-16.9 years after IFN therapy, respectively. Before receiving IFN therapy, 92 (71%) patients had cirrhosis and/or a low platelet count (<15×10(4) cells/μL). Lower albumin (<3.9 g/dL) and higher alpha fetoprotein (AFP) (≥10 ng/mL) levels were identified in a multivariate analysis to be independent variables of the development of HCC within five years after IFN therapy. Among 4,542 SVR patients, HCC occurred in 109 (2.4%) during a 5.5-year follow-up period, thus resulting in an occurrence rate of 4.6% for men and 0.6% for women. CONCLUSION: SVR patients with lower albumin or higher AFP levels require careful assessments to prevent early HCC development after IFN therapy. HCC occurrence within >10 years of IFN therapy is not uncommon, and the risk factors remain uncertain, thus suggesting that all SVR patients should undergo long-term follow-up examinations for HCC development.
Source: Internal Medicine
Authors: Akira Sato, Michio Sata, Kenji Ikeda, Takashi Kumada, Namiki Izumi, Yasuhiro Asahina, Yukio Osaki, Kazuaki Chayama, Shuichi Kaneko, Akito Sakai, Morikazu Onji, Yoichi Hiasa, Takumi Omura, Itaru Ozeki, Osamu Yokosuka, Shuichiro Shiina, Mariko Itsubo, Shuhei Nishiguchi, Katsuharu Hirano, Tatsuya Ide, Shotaro Sakisaka, Takahiro Yamasaki, Isao Hidaka, Masatoshi Tanaka, Soo Ryang Kim, Takafumi Ichida
Institutions: St. Marianna University School of Medicine, Yokohama City Seibu Hospital, Kurume University, Toranomon Hospital, Ogaki Municipal Hospital, Musashino Red Cross Hospital, Osaka Red Cross Hospital, Hiroshima University, Kanazawa University, Ehime University, Sapporo Kosei General Hospital, Chiba University, The University of Tokyo, Jikei University School of Medicine, Hyogo Medical University, Juntendo University Shizuoka Hospital, Fukuoka University, Yamaguchi University, Kurume University Medical Center, Kobe Asahi Hospital
Language: English
Topic: Hepatitis C virus research
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Innate immunity and treatment response in chronic viral hepatitis, Impaired host response and HCV disturbance of type I/III IFN signaling are closely associated with non-response to IFN-based anti-HCV treatment, Human iPS-derived hepatocyte-like progenitor cells susceptible for hepatitis B virus infection
OpenAlex ID: W2000755883