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Potent Retinoid Synergists with a Diphenylamine Skeleton.

Year: 1998

Type: article

Abstract: 4-[N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)amino]benzoic acid (5) exhibited weak retinoidal and retinoid synergistic activities in HL-60 cell differentiation assay. N-Alkylation of 5 caused decrease or loss of differentiation-inducing activity, but enhanced the synergistic activity with a synthetic retinoid Am80 (2), as reflected in the potent synergistic EC50 (SEC50) values of DA023 (11, 1.6 x 10(-10) M) and DA113 (14, 1.4 x 10(-10) M) in the presence of 1.0 x 10(-10) M Am80 (2).

Source: Biological and Pharmaceutical Bulletin

DOI: 10.1248/bpb.21.544

Authors: Kiminori OHTA, Motonori TSUJI, Emiko KAWACHI, Hiroshi FUKASAWA, Yuichi HASHIMOTO, Koichi SHUDO, Hiroyuki KAGECHIKA

Institution: The University of Tokyo

Language: English

Topic: Retinoids in leukemia and cellular processes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2000917518

FWCI: 0.291

Cites:

Cited by: 25

Related to: 10