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Altered striatal response to reward in bulimia nervosa after recovery

Year: 2009
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: It is possible that disturbances of systems modulating reward may contribute to a vulnerability to develop an eating disorder. METHOD: This hypothesis was tested by assessing functional magnetic resonance brain imaging response to a monetary reward task known to activate the anterior ventral striatum (AVS), a region implicated in motivational aspects toward stimuli. To avoid the confounding effects of malnutrition, 10 women who had recovered from bulimia nervosa (BN) were compared with 10 healthy comparison women (CW). RESULTS: For the AVS, CW distinguished positive and negative feedback, whereas recovered BN women had similar responses to both conditions. In addition, these groups had similar patterns of findings for the dorsal caudate. DISCUSSION: We have previously shown that individuals recovered from anorexia nervosa (AN) also had altered striatal responses and difficulties in differentiating positive and negative feedback. Thus BN and AN individuals may share a difficulty in discriminating the emotional significance of a stimulus.
DOI: 10.1002/eat.20699
Authors: Angela Wagner, Howard Aizenstein, Vijay K. Venkatraman, Amanda Bischoff‐Grethe, Julie Fudge, J. Christopher May, Guido K. Frank, Ursula F. Bailer, Lorie Fischer, Karen Putnam, Walter H. Kaye
Institutions: University of Pittsburgh, University of California San Diego, University of Rochester Medicine, University of Rochester, Center for the Neural Basis of Cognition, Children's Hospital Colorado, University of Colorado Denver, Medical University of Vienna, University of Cincinnati
Language: English
Field: Psychology
Open Access status: green
Awards: PET IMAGING AND SEROTONIN LIGANDS IN EATING DISORDERS, G201233509, G3457690910, Serotonin - A Trait Disturbance in Anorexia Nervosa?, Brain Reward-Pathway Function and Neurocomputational Modeling in Anorexia Nervosa, Neurobiology of Anorexia and Bulimia Nervosa, Fellowship in Biological Psychiatry and Neuroscience
OpenAlex ID: W2000938423
FWCI: 9.046
Cites: 34
Cited by: 92
Related to: 10