Work

Absence of a Mutation of the p21/WAF1 Gene in Human Lung and Pancreatic Cancers

Year: 1996

Type: article

Abstract: The expression of a negative regulator of the cell cycle, p21WAF1 protein, is trans-activated by wild-type p53, but not by the mutant protein. Therefore, mutations of the p53 and WAF1 genes may be complementary. We examined DNAs from 70 human primary lung (63 of NSCLC and 7 of SCLC) and 24 pancreatic cancers (19 primary cancers and 5 cell lines) for mutations of the WAF1 gene. No mutations were detected in any samples examined, regardless of the mutational state of the p53 gene. The results suggested that aberrations of the coding sequence of the WAF1 gene are not associated with carcinogenesis in lung and pancreatic cancers.

Source: Japanese Journal of Cancer Research

DOI: 10.1111/j.1349-7006.1996.tb00217.x

Authors: Tatsunori Shimizu, Wataru Miwa, Shoji Nakamori, Osamu Ishikawa, Yoichi Konishi, Takao Sekiya

Institutions: National Cancer Center Research Institute, Nara Medical University

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2001293469

FWCI: 3.365

Cites: 19

Cited by: 32

Related to: 10