Work

Modelling the effects of combining pre-erythrocytic vaccines against Plasmodium falciparum

Year: 2014

Type: article

Abstract: Background A high efficacy multi-stage multi-epitope malaria vaccine would be an invaluable weapon in the eradication of malaria. Currently, the best progress in subunit vaccine research has been seen in targeting pre-erythrocytic (PE) stages of the parasite. In phase IIa trials, RTS,S in adjuvant was capable of inducing sterile protection in 50% of individuals [1], and ME-TRAP in a heterologous prime-boost regime saw around 21% efficacy [2]. Here we present a mathematical model investigating the effects of combining these two approaches.

Source: Malaria Journal

DOI: 10.1186/1475-2875-13-s1-p90

Authors: Andrew Walker, Sunetra Gupta

Institution: University of Oxford

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,890