Year: 2004
Type: article
Abstract: Weakly activated signaling cascades can be modeled as linear systems. The input-to-output transfer function and the internal gain of a linear system provide natural measures for the propagation of the input signal down the cascade and for the characterization of the final outcome. The most efficient design of a cascade for generating sharp signals is obtained by choosing all the off rates equal and a “universal” finite optimal length.
DOI: 10.1021/jp048935f
Institution: Rutgers, The State University of New Jersey
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2002045347