Work

A User's Guide to the NINDS rt-PA Stroke Trial Database

Year: 2008

Type: article

Abstract: Points• In 1995, the NINDS rt-PA study documented an improvement in neurologic outcomes at three months for those patients given rt-PA within 3 hours of onset of an acute ischemic stroke.• This trial has become the sentinel study supporting the use of rt-PA in acute ischemic stroke.• Questions raised regarding this trial have been diffi cult to answer, since the raw data have been unavailable to non-NINDS researchers.• In October 2003, the data from this trial became available for purchase.• In this report, we describe the process of acquiring and deciphering the dataset from the original trial, provide a detailed description of the dataset, and discuss the implications for potential future research.

Source: PLoS Medicine

DOI: 10.1371/journal.pmed.0050113

Authors: Robert J Dachs, John H Burton, Jeremy Joslin

Institutions: Ellis Hospital, National Institute of Neurological Disorders and Stroke, Albany Medical Center Hospital

Language: English

Topic: Acute Ischemic Stroke Management

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,460