Year: 2003
Type: article
Abstract: The feasibility of using a metabolite signal as an internal reference for self-referenced temperature distribution measurement was examined. Line scan echo-planar spectroscopic imaging (LSEPSI) was applied to obtain quick multi-voxel spectroscopic measurements and to avoid possible spectral degradation from motion. Temperature distribution in a rabbit brain in vivo was successfully visualized by means of the chemical shift of water, which was measured by using naturally abundant (up to 10 mM) N-acetyl-aspartate (NAA) as the reference signal. Unlike the phase-mapping approach, this technique does not require a pixel-by-pixel subtraction. Therefore, in theory, it is more resistant to inter-scan motion or changes in susceptibility. The spatial and temporal resolutions of this technique are 1.5 cm3 and 4.5 min. A higher signal-to-noise ratio and optimization of the water and outer-volume suppression capabilities will be required to further enhance the temperature-mapping capabilities.
DOI: 10.2463/mrms.2.17
Institutions: Brigham and Women's Hospital, Tokai University, Harvard University, Institute for Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation, Research Institute of Science and Technology, Tokai University, GE HealthCare (Japan), National Institute of Advanced Industrial Science and Technology, University of Tsukuba
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funder: Brigham and Women's Hospital
OpenAlex ID: W2002575390