Risk factor profile for chronic kidney disease is similar to risk factor profile for small artery disease
Year: 2011
Type: article
Study design: Observational Study
Abstract: BACKGROUND AND METHOD: We investigated whether chronic kidney disease detected by increased serum creatinine (S(Cr)) or urine albumin-to-creatinine ratio (U(ACR)) may reflect arteriosclerosis involving the kidneys. The sample consisted of 1585 members of sibships (804 non-Hispanic whites and 781 non-Hispanic blacks) in which at least two siblings had primary hypertension. We first evaluated the correlations of increased S(Cr) and U(ACR) with the presence of cerebral small vessel arteriosclerosis, which was determined by increased subcortical white matter hyperintensity (WMH) volume on brain magnetic resonance imaging; and with peripheral large vessel arteriosclerosis, which was determined by decreased ankle-brachial index (ABI). After age adjustment, increased S(Cr) and U(ACR) correlated with increased WMH volume (0.54 and 0.52, respectively) and with decreased ABI (0.50 and 0.54, respectively; all P < 0.001). We then used logistic regression to evaluate the dependency of each measure of disease on conventional risk factors for arteriosclerosis to assess whether the risk factors' effects were proportional across different measures of disease. RESULTS: Age, race, sex, hypertension, diabetes, total cholesterol, and smoking made similar overall contributions to the prediction of each measure of disease, as judged by the model C-statistics, which varied in a narrow range from 0.84 to 0.85 (all P < 0.001). However, the relative contributions that the modifiable risk factors, including hypertension, diabetes, total cholesterol, and smoking made to prediction of increased S(Cr) and U(ACR) were disproportionate to their relative contributions to prediction of decreased ABI (P < 0.0001). CONCLUSION: The findings support the view that chronic kidney disease detected by increased S(Cr) or U(ACR) primarily reflects small vessel arteriosclerosis involving the kidneys.
Source: Journal of Hypertension
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Novel approaches in linkage analysis for complex traits, GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPS, Genetics of Microangiopathic Brain Injury, General Clinical Research Center, GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPS, Improving stone disease treatment by accurate phenotyping and risk stratification, NHLBI FAMILY BLOOD PRESSURE PROGRAM (GENOA), The Family Blood Pressure Program (GENOA Network), Automated detection of microstructural features that have unique protein markers and are prognostic for chronic kidney disease
OpenAlex ID: W2002604554