Work

Subjective and objective assessment of enalapril in primary Raynaud's phenomenon.

Year: 1991

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: 1. The efficacy and acceptability of enalapril were assessed in a double-blind, randomised, placebo controlled cross-over study in 21 patients with primary Raynaud's phenomenon. 2. Skin temperature was assessed by thermocouples in response to a 15 degrees C cold water challenge as an index of digital blood flow. 3. Following enalapril there were no significant changes in the number and severity of Raynaud's attacks, and no subjective benefit from treatment as measured by visual analogue scales, 5 point rating scales, and skin temperature response to cold challenge when compared with placebo. 4. Enalapril in a dose of 20 mg daily is ineffective in the management of primary Raynaud's phenomenon.

Source: British Journal of Clinical Pharmacology

DOI: 10.1111/j.1365-2125.1991.tb05565.x

Authors: VF Challenor, DG Waller, RA Hayward, MJ Griffin, OS Roath

Institution: Southampton General Hospital

Language: English

Topic: Systemic Sclerosis and Related Diseases

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2003083300

FWCI: 0.658

Cites: 17

Cited by: 27

Related to: 10