Work

Synthesis and Evaluation of Adenosine Antagonist Activity of a Series of [1,2,4]Triazolo[1,5-c]quinazolines

Year: 2007

Type: article

Abstract: A series of [1,2,4]triazolo[1,5-c]quinazolines were prepared in satisfactory yields by reaction of some derivatives of 2-aminobenzohydrazide with several hydrochlorides of aromatic amidines, and their binding affinities for the recombinant human adenosine A2A and A2B receptors were determined. None of the new compounds showed noteworthy affinity for these receptors, though a very high affinity for the A2A receptor and, consequently, a high level of A2A/A2B selectivity was revealed for one of the synthesized compounds.

Source: Chemical and Pharmaceutical Bulletin

DOI: 10.1248/cpb.55.372

Authors: Carmen Balo, Carmen López, José Manuel Brea, Franco Fernánde, Olga Caamaño

Institution: Universidade de Santiago de Compostela

Language: English

Topic: Adenosine and Purinergic Signaling

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2003137448

FWCI: 0.957

Cites: 16

Cited by: 28

Related to: 10