Year: 1984
Type: article
Abstract: The antimicrobial food additive AF-2 is mutagenic in bacteria, Neurospora, yeast and Drosophila. AF-2 breaks mammalian chromsomes. We studied by Feulgen staining the types and distribution of chromosome aberrations induced by AF-2 in Vicia faba root meristems. AF-2 induces (a) mitostasis resulting in accumulation of cells in G1, S or G2 phase, (b) chromosome condensation, (c) pycnosis of the interphase nuclei and (d) anaphase bridges and micronuclei. The bridges involve all the six chromosome pairs but largely the SAT-chromosomes. Attachments are confined to secondary constrictions and chromosome tips. These effects are likely to be due to an indirect action of AF-2 on the genetic material.
Source: CYTOLOGIA
Authors: H. N. B. Gopalan, G. D. E. Njagi
Institutions: University of Nairobi, Kenyatta University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2003160422