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Biological Activity of Antibiotic G-418, a New Micromonospora -Produced Aminoglycoside with Activity Against Protozoa and Helminths

Year: 1974

Type: article

Abstract: On the basis of parallel in vitro studies with antibiotic G-418, gentamicin, neomycin, and kanamycin, antibiotic G-418 was found to be less potent than gentamicin but more active than either kanamycin or neomycin against most strains, with the exception of Pseudomonas, for which neomycin was more active than antibiotic G-418, and enterococci, for which antibiotic G-418 was more active than the other three antibiotics. Mouse protection tests indicated that antibiotic G-418 is approximately half as potent as gentamicin and its acute toxicity is one-half to one-third that of gentamicin.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.6.5.579

Authors: J. A. Waitz, F. Sabatelli, F. Menzel, E. L. Moss

Language: English

Topic: Antibiotics Pharmacokinetics and Efficacy

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2003755380

FWCI: 0.342

Cites: 2

Cited by: 22

Related to: 10