A transparent broadband ultrasonic detector based on an optical micro-ring resonator for photoacoustic microscopy
Year: 2014
Type: article
Abstract: Photoacoustic microscopy (PAM) does not rely on contrast agent to image the optical absorption contrast in biological tissue. It is uniquely suited for measuring several tissue physiological parameters, such as hemoglobin oxygen saturation, that would otherwise remain challenging. Researchers are designing new clinical diagnostic tools and multimodal microscopic systems around PAM to fully unleash its potential. However, the sizeable and opaque piezoelectric ultrasonic detectors commonly used in PAM impose a serious constraint. Our solution is a coverslip-style optically transparent ultrasound detector based on a polymeric optical micro-ring resonator (MRR) with a total thickness of 250 μm. It enables highly-sensitive ultrasound detection over a wide receiving angle with a bandwidth of 140 MHz, which corresponds to a photoacoustic saturation limit of 287 cm(-1), at an estimated noise-equivalent pressure (NEP) of 6.8 Pa. We also established a theoretical framework for designing and optimizing the MRR for PAM.
Source: Scientific Reports
DOI: 10.1038/srep04496
Authors: Hao Li, Biqin Dong, Zhen Zhang, Hao F. Zhang, Cheng Sun
Institution: Northwestern University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,690
Awards: G1205859515, G1268790672, G1972581785, G2674981899, Integrated Multidisciplinary Strategies for Detection of Diabetic Retinopathies, Multimodal Retinal Functional Imaging for Diabetic Retinopathy, Collaborative Research in Biophotonics: Towards high-resolution, label-free molecular imaging in deep tissue via stimulated Raman excitation and ultrasound detection, G4439475616, G468595751, G4818883579, CAREER: Functional imaging to prevent blindness, CAREER: A Hybrid Approach for Flexible Nanomanufacturing - Maskless Plasmonic Nano-Lithography, NSEC: Center for Scalable and Integrated Nanomanufacturing (SINAM), G7803881714, G7873484468, G9000115067, G949422507
OpenAlex ID: W2004196471