Work

In vitro anti-leishmanial activities of germatranyl and Silicon incorporated diorganotin derivatives: Synthesis and spectroscopic properties

Year: 2008

Type: article

Abstract: A series of germanium and silicon incorporated diorganotin derivatives of general formula [N(OCH2CH2)3GeCH(R(1)CH2CO2]2 SnR2(2) where R1 = H3C, C6H5, p-CH3C6H4, p-FC6H4; R2 = H2CSi(CH3)2C6H5, H2CC6H5, p-CH3C7H7 were synthesized by the reaction of appropriate diorganotin dichlorides and germatranyl (substituted) propionic acid in 1:2 mole ratio, respectively. The evidence regarding their structure is mainly based on spectroscopic data obtained by multinuclear (1H, 13C, 29Si, 119Sn) NMR and 119mSn Mössbauer, IR and mass spectral studies in combination with melting points and elemental analyses. The compounds have been screened for in vitro anti-leishmanial activity against promastigotes of Leishmania major and the results offer potent activities which are better than the standard drug, pentamidine, for one compound.

Source: Journal of Enzyme Inhibition and Medicinal Chemistry

DOI: 10.1080/14756360802188123

Authors: U. Salma, M. Mazhar, Imtiaz-ud -Din, S. Ali, Khalid M. Khan

Institutions: Quaid-i-Azam University, University of Karachi, International Center for Chemical and Biological Sciences

Language: English

Topic: Organometallic Compounds Synthesis and Characterization

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2004271444

FWCI: 0.331

Cites: 20

Cited by: 6

Related to: 10