Work

Prevalence of drug resistance mutations in HIV-1 protease gene from North India

Year: 2012

Type: article

Abstract: Results Among 35 patients, there were 17 drug naive and 18 first line drugs experienced HIV-1 infected patients (22 males & 13 females; mean age: 35.95 years; mean CD4 cells: 216.4cells/mm). Majority of our patients showed mutations at T12S/T (82.85%), K14R (40%), I15V (71.42%), L19I/T/V/M (97.14%), M36I (71.42%), R41K (88.57%), L63P (65.71%), H63K (100%) and L89M (74.28%) positions in both group of patients while other mutations were at positions 35, 37, 45, 60, 62, 77, and 82 in few cases. Interestingly, one first line drug experienced patient showed major DR mutations at D30N and M46I positions. Majority (94.28%) was belonging to subtype C and 2 patients were belonging to subtypes A (A1).

Source: BMC Infectious Diseases

DOI: 10.1186/1471-2334-12-s1-p84