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Effect of Idebenone (CV-2619) on Memory Impairment Observed in Passive Avoidance Task in Rats with Cerebral Embolization

Year: 1985

Type: article

Abstract: Effect of idebenone (CV-2619) on memory impairment was studied in rats with cerebral embolization. The cerebral embolization, produced by injecting 2000 microspheres into the internal carotid artery, caused a significant impairment in passive avoidance response. Repeated administrations of idebenone (30 mg/kg/day, i.p.), partially but significantly improved the impairment of the passive avoidance response in the embolized rats. The results suggest that the repeated administration of idebenone exerts an ameliorating effect on memory impairment induced by cerebral embolization.

Source: The Japanese Journal of Pharmacology

DOI: 10.1254/jjp.37.300

Authors: Yoshihiro KIYOTA, Kazuhiro HAMAJO, Masaomi MIYAMOTO, Akinobu NAGAOKA

Institution: Takeda (Japan)

Language: English

Topic: Neurological Disease Mechanisms and Treatments

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2004602091

FWCI: 3.676

Cites: 8

Cited by: 52

Related to: 10