Work

Monitoring cell-cycle-related viscoelasticity by a quartz crystal microbalance

Year: 2006

Type: article

Abstract: We have monitored viscoelasticity variation of a cell population during the cell cycle by a Quartz Crystal Microbalance (QCM). Balb 3T3 fibroblasts were synchronized in the G0/G1 phase and seeded in a QCM chamber placed in a cell incubator. After cell sedimentation, the frequency signal was characterized by an amplitude modulation attributed to the viscoelasticity variation of the cells proliferating in phase. A control experiment with nonsynchronized cells showed a similar signal trend, but without significant modulation. Interestingly, the system resulted also to perform as a device sensitive to the effect of drugs affecting the cell cycle, such as colchicine.

Source: Applied Physics Letters

DOI: 10.1063/1.2177647

Authors: A. Alessandrini, M. A. Croce, R. Tiozzo, P. Facci

Institutions: National Research Council, University of Modena and Reggio Emilia

Language: English

Topic: Acoustic Wave Resonator Technologies

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W2004679697

FWCI: 4.593

Cites: 33

Cited by: 33

Related to: 10