Work

Distribution of Human Immunodeficiency Virus Type 1 Protease and Reverse Transcriptase Mutation Patterns in 4,183 Persons Undergoing Genotypic Resistance Testing

Year: 2004

Type: article

Abstract: In a sample of 6,156 sequences from 4,183 persons, the top 30 patterns of protease inhibitor, nucleoside reverse transcriptase (RT) inhibitor, and nonnucleoside RT inhibitor mutations accounted for 55, 46, and 66%, respectively, of sequences with drug resistance mutations. Characterization of the phenotypic and clinical significance of these common patterns may lead to improved treatment recommendations for a large proportion of patients for whom antiretroviral therapy is failing.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.48.8.3122-3126.2004

Authors: Soo-Yon Rhee, Tommy Liu, Jaideep Ravela, Matthew J. Gonzales, Robert W. Shafer

Institutions: Stanford Medicine, Stanford University

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2004800530

FWCI: 4.001

Cites: 8

Cited by: 104

Related to: 10