Host-Derived IL-22 Protects Intestinal Stem Cells from GVHD
Year: 2012
Type: article
Abstract: IL-22 is a recently characterized cytokine that is produced by helper T cells and innate lymphoid cells (ILC). Expression of its receptor (IL-22R) is limited to non-hematopoietic stromal cells, and it mediates protection of intestinal epithelium during experimental colitis by providing a signal for epithelial cell survival, proliferation, and wound healing. We investigated the role of IL-22 in GVHD during MHC-mismatched C57BL/6 (B6) into BALB/c murine bone marrow transplantation (BMT). Elimination of IL-22 with neutralizing antibody led to increased GVHD mortality post-BMT in comparison to isotype control.
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2004993703