Work

Versatile assembly of 5-aminothiazoles based on the Ugi four-component coupling

Year: 2008

Type: article

Abstract: A flexible route to novel 5-aminothiazoles has been developed based on cyclisation of diamide adducts, prepared using the Ugi reaction , in the presence of Lawesson’s reagent. The Walborsky reagent (1,1,3,3-tetramethylbutyl isocyanide) was used as the isonitrile component, facilitating subsequent deprotection of the N -alkyl group to yield free 5-aminothiazoles, which were prepared with a variety of substituents at the 2- and 4-positions.

Source: Tetrahedron Letters

DOI: 10.1016/j.tetlet.2008.06.067

Authors: Mark J. Thompson, Beining Chen

Institution: University of Sheffield

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,610

Funder: Biotechnology and Biological Sciences Research Council