Hepatorenal toxicity studies of sub-chronic administration of calyx aqueous extracts of hibiscus sabdariffa in albino rats
Year: 2010
Type: article
Abstract: Hibiscus sabdariffa Linn has been reported to have a broad range of therapeutic effects. Subchronic effects of calyces aqueous extracts of H. Sabdariffa were studied in albino rats. Twenty four (24) albino rats were randomly divided into six (6) groups of four rats each. Group A, was fed with growers mesh and distilled water as control. Groups B to F were administered orally with the aqueous extract at 1, 2, 3, 4 and 5g /kg body weight respectively and the treatment period was 28 days. A decreased in weights of the animals were observed at all dose levels. The activities of liver maker enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase) and direct bilirubin increased significantly (p0.05) increase in concentrations of total protein and albumin were observed in comparison to the control. The renal indices, urea, uric acid and creatinine in the treated groups were significantly increased compared to the control but a significant decrease (p
Authors: M Abubakar, A Lawal, B Suleiman, K Abdullahi
Institution: Usmanu Danfodiyo University
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2005161491