Year: 2014
Type: article
Study design: Observational Study
Abstract: PURPOSE: Human papillomavirus (HPV) is a major risk factor for specific cancers of the head and neck, particularly malignancies of the tonsil and base of the tongue. However, the role of HPV in the development of laryngeal cancer has not been definitively established. We conducted a population-based, cancer registry study to evaluate and characterize the genotype-specific prevalence of HPV in invasive laryngeal cancer cases diagnosed in the U.S. METHODS: The presence of genotype-specific HPV DNA was evaluated using the Linear Array HPV Genotyping Test and the INNO-LiPA HPV Genotyping Assay in formalin-fixed paraffin embedded tissue from 148 invasive laryngeal cancer cases diagnosed in 1993-2004 within the catchment area of three U.S. SEER cancer registries. RESULTS: HPV DNA was detected in 31 of 148 (21%) invasive laryngeal cancers. Thirteen different genotypes were detected. Overall, HPV 16 and HPV 33 were the most commonly detected types. HPV was detected in 33% (9/27) of women compared with 18% (22/121) of men (p = 0.08). After adjustment for age and year of diagnosis, female patients were more likely to have HPV-positive laryngeal tumors compared to males (adjusted OR 2.84, 95% CI 1.07-7.51). Viral genotype differences were also observed between the sexes. While HPV 16 and 18 constituted half of HPV-positive cases occurring in men, among women, only 1 was HPV 16 positive and none were positive for HPV 18. Overall 5-year survival did not vary by HPV status. CONCLUSIONS: HPV may be involved in the development of a subset of laryngeal cancers and its role may be more predominant in women compared to men.
Source: PLoS ONE
Authors: Brenda Y. Hernandez, Marc T. Goodman, Charles F. Lynch, Wendy Cozen, Elizabeth R. Unger, Martin Steinau, Trevor Thompson, Maria Sibug Saber, Sean F. Altekruse, Christopher Lyu, Mona Saraiya, The HPV Typing of Cancer Workgroup
Institutions: University of Hawaii Cancer Center, Cedars-Sinai Medical Center, University of Iowa, University of Southern California, USC Norris Comprehensive Cancer Center, Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, National Center for Chronic Disease Prevention and Health Promotion, National Institutes of Health, National Cancer Institute, Battelle
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,382
Awards: Surveillance, Epidemiology and End Results (SEER) Program - Iowa, G1288623819, G1891143572, G1932976417, G2089898225, #14: Residual Tissue Repository to Create HIV Cancer Tumor Tissue Microrarrays , G2590553186, G2925750098, G3205575695, G3438245392, G3651850380, WS No. 12 Patterns of Care DX Year 2008, G4146105916, G667355291, G6718950571, G702041046, G7033391325, G7278087418
OpenAlex ID: W2005178478